After maturation, in primary lymphoid organs, the lymphocytes migrate for interaction with antigens to secondary
lymphoid organ(s) / tissue(s) like
A.   thymus
B.   bone marrow

C.   spleen

D.    lymph nodes

E.    Peyer’s patches

Choose the correct answer from the options given below

When lymphocytes finish maturing in the primary lymphoid organs (the thymus for T cells and the bone marrow for B cells), they must encounter antigens in order to become activated.

Antigen encounter takes place in secondary lymphoid tissues, which provide specialized environments for immune cells to interact with foreign substances and each other.

The key secondary lymphoid locations that mature lymphocytes migrate to are:

• Spleen – filters the blood, presents antigens from circulating pathogens, and supports activation of both B‑cells and T‑cells.

• Lymph nodes – positioned along lymphatic vessels, they filter lymph, present antigens from peripheral tissues, and facilitate cell‑cell communication.

• Peyer’s patches – clusters of lymphoid tissue in the small‑intestine wall that sample antigens from the gut lumen and initiate immune responses to intestinal microbes.

The thymus (A) and bone marrow (B) are primary lymphoid organs where the maturation process occurs, not destinations for mature lymphocytes seeking antigens.

Thus, the correct answer is C, D, E only.