Arrange the following events occurring in Renin-Angiotensin mechanism in the correct order :

A. Increase in blood pressure and Glomerular filtration rate.
B. Reabsorption of Na+ and water from distal parts of tubule due to Aldosterone.
C. Fall in Glomerular filtration rate.
D. Vasoconstriction by Angiotensin II and release of Aldosterone.
E. Renin converts Angiotensinogen into Angiotensin I, followed by Angiotensin II.

Choose the correct answer from the options given below :

In the renin‑angiotensin system the cascade begins when the kidney senses a drop in glomerular filtration pressure, which triggers a fall in the glomerular filtration rate (GFR). This is event C.

Because GFR is reduced, the juxtaglomerular cells release renin. Renin then cleaves circulating angiotensinogen (produced by the liver) into angiotensin I, which is subsequently converted to angiotensin II by angiotensin‑converting enzyme (ACE). This sequence corresponds to event E.

Angiotensin II has two major actions: it causes powerful vasoconstriction, raising systemic blood pressure, and it stimulates the adrenal cortex to secrete aldosterone. Both actions are described in event D.

Aldosterone acts on the distal nephron (principal cells of the distal tubule and collecting duct) to increase reabsorption of Na⁺ and water, which helps to restore blood volume and pressure. This is event B.

Finally, the increased blood volume and systemic vasoconstriction lead to a rise in both blood pressure and the glomerular filtration rate, completing the feedback loop. This is event A.

Putting the events together in the order they occur yields the sequence: C, E, D, B, A.