Find the correct statement :

(A) In human pregnancy, the major organ systems are formed at the end of 12 weeks.
(B) In human pregnancy the major organ systems are formed at the end of 8 weeks.
(C) In human pregnancy heart is formed after one month of gestation.
(D) In human pregnancy, limbs and digits develop by the end of second month.
(E) In human pregnancy the appearance of hair is usually observed in the fifth month.
Choose the correct answer from the options given below :

To determine which statements are correct we compare each claim with the established timeline of human fetal development.

Statement A: “In human pregnancy, the major organ systems are formed at the end of 12 weeks.”
During the first trimester (up to 12 weeks) the process of organogenesis is completed, establishing the basic architecture of the major organ systems. Therefore this statement is **true**.

Statement B: “In human pregnancy the major organ systems are formed at the end of 8 weeks.”
Although many organ primordia appear by 8 weeks, the full formation and differentiation of the major systems is not finished until the end of the first trimester (≈12 weeks). Hence this statement is **false**.

Statement C: “In human pregnancy heart is formed after one month of gestation.”
The cardiac tube begins to develop at about 3–4 weeks, and a functional heartbeat can be detected around the 4‑week mark (≈one month). Thus the heart is indeed formed after the first month, making the statement **true**.

Statement D: “In human pregnancy, limbs and digits develop by the end of second month.”
Limb buds appear around week 4 and the digital rays (fingers and toes) become recognizable by week 8, which is the end of the second month. This matches the claim, so the statement is **true**.

Statement E: “In human pregnancy the appearance of hair is usually observed in the fifth month.”
Lanugo, the fine fetal hair, typically begins to cover the body around 20 weeks, i.e., the fifth month of gestation. Therefore this statement is **true**.

Summarizing the truth values:

• A – true
• B – false
• C – true
• D – true
• E – true

The combination of true statements corresponds to **A, C, D and E only**.