Nucleosome is associated with ________molecules of histones.

The correct option is Eight.

To understand why this option is correct, let's break down the structure of a nucleosome:
1. A nucleosome is the fundamental repeating unit of chromatin in eukaryotic cells, which helps package long DNA molecules into a compact structure.
2. Each nucleosome consists of a segment of DNA wound around a protein core.
3. This protein core is an octamer, meaning it is made up of exactly eight histone protein molecules. Specifically, it contains two copies each of four core histones: H2A, H2B, H3, and H4.
4. Therefore, the nucleosome core particle is associated with eight molecules of histones.