Question Details

Select the observations drawn from the human genome project which are correct.


(A) The human genome contains 3164.7 million bp.
(B) The average gene consists of 3000 bases.
(C) Total number of genes is estimated at 30,000.
(D) The functions are unknown for over 50% of discovered genes.
(E) Less than 2% of the genome codes for proteins.


Choose the correct answer from the options given below:

Options

A

(A), (B), (C) and (D) only

B

(A), (C), (D) and (E) only

C

(A), (C) and (E) only

D

(A), (B), (C), (D) and (E)

Show Answer

Correct Answer :

Option D

(A), (B), (C), (D) and (E)

Solution :

The correct answer is (A), (B), (C), (D) and (E).

The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and identifying, mapping, and sequencing all of the genes of the human genome. The major observations and findings of the Human Genome Project include the following:

Statement (A) is correct: The human genome is incredibly vast and contains approximately 3164.7 million (or about 3.16 billion) chemical base pairs (bp) in the haploid genome.
Statement (B) is correct: Genes vary greatly in size. For instance, the largest known human gene is dystrophin, which spans 2.4 million bases. However, the average size of a human gene is estimated to be approximately 3,000 bases.
Statement (C) is correct: Prior to the HGP, scientists estimated that humans had over 100,000 genes. HGP findings dramatically lowered this estimate, revealing that the total number of genes is estimated at around 30,000 (with current estimates for protein-coding genes hovering between 20,000 and 25,000).
Statement (D) is correct: Even though thousands of genes were successfully mapped and sequenced, the exact biological functions remain unknown for over 50% of the discovered genes.
Statement (E) is correct: Only a very small portion of the human genome actively directs the synthesis of proteins. Less than 2% of the entire genome codes for proteins, while the rest consists of non-coding sequences, repetitive DNA, and regulatory regions.

Since all the given statements are verified findings of the Human Genome Project, they are all correct.

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