The first Indigenous vaccine of COVID-19 developed in India was....

The correct option is COVAXIN.

Here is the step-by-step educational explanation of why COVAXIN is the correct answer:

1. Understanding "Indigenous Vaccine":
An indigenous vaccine refers to a vaccine that is completely developed and manufactured within a specific country using local research, development, and resources.

2. Analyzing the Options:

• COVAXIN: This vaccine (codenamed BBV152) was developed by Bharat Biotech, an Indian biotechnology company, in collaboration with the Indian Council of Medical Research (ICMR) and the National Institute of Virology (NIV). Since the research, isolation of the virus strain, and manufacturing were all done locally in India, it is recognized as India's first indigenous COVID-19 vaccine.
• COVISHIELD: Although manufactured by the Serum Institute of India (SII), COVISHIELD was originally developed by the Oxford-AstraZeneca partnership (a British-Swedish collaboration). Hence, it is not an indigenous Indian vaccine.
• SPUTNIK-V: This vaccine was developed by the Gamaleya Research Institute of Epidemiology and Microbiology in Russia.
• MODERNA: This mRNA vaccine was developed by the American biotechnology company Moderna, Inc.

Therefore, COVAXIN is the first indigenous COVID-19 vaccine developed in India.