The government of India in November 1948 appointed a University Education Commission under the Chairmanship of:

The correct option is Dr. S. Radhakrishnan.

Detailed Explanation:
Following India's independence, the Government of India appointed the University Education Commission in November 1948. The primary objective of the commission was to study the status of university education in India and suggest improvements and extensions to suit the present and future requirements of the nation.
The commission was set up under the chairmanship of the eminent philosopher, scholar, and statesman, Dr. Sarvepalli Radhakrishnan, who later became the first Vice-President and the second President of India. Due to his chairmanship, this commission is also popularly known as the Radhakrishnan Commission. It submitted its comprehensive report in August 1949, which paved the way for the establishment of the University Grants Commission (UGC) in 1953.

Overview of other options:
• D.S. Kothari: Dr. Daulat Singh Kothari was the chairperson of the Education Commission of 1964–1966, which is popularly known as the Kothari Commission.
• Ms. Sucheta Kriplani: She was a prominent freedom fighter and India's first female Chief Minister (serving Uttar Pradesh), but did not chair this education commission.
• Mrs. Annie Besant: She was an influential political activist, freedom fighter, and theosophist who played a major role in the Indian Home Rule movement, but she passed away in 1933, well before the commission was formed.