Which of the following hormones released from the pituitary is actually synthesized in the hypothalamus?

To answer the question we need to identify which pituitary hormone is actually made in the hypothalamus before being released into the bloodstream.

The pituitary gland has two distinct parts:

1. Anterior pituitary (adenohypophysis) – synthesizes and secretes its own hormones such as FSH, LH, and ACTH.
2. Posterior pituitary (neurohypophysis) – does not synthesize hormones; it stores and releases hormones that were produced by neurons in the hypothalamus.

Among the listed options:

- Follicle‑stimulating hormone (FSH) – produced by the anterior pituitary.
- Luteinizing hormone (LH) – produced by the anterior pituitary.
- Adrenocorticotropic hormone (ACTH) – produced by the anterior pituitary.

Anti‑diuretic hormone (ADH), also known as vasopressin, is synthesized in the magnocellular neurons of the hypothalamic supraoptic and paraventricular nuclei. After synthesis, ADH is transported down the axons of these neurons and stored in the axon terminals located in the posterior pituitary, from where it is released into the circulation.

Therefore, the only hormone in the list that is actually synthesized in the hypothalamus is Anti‑diuretic hormone (ADH).