Which of the following letter-number clusters will replace the question mark (?) in the given series to make it logically complete?
HBE22 ICF29 JDG36 KEH43 ?

The correct option is LFI50.

To find the missing letter-number cluster in the series, let us analyze the pattern for each position step-by-step.

Step 1: Analyze the first letter of each cluster
The first letters are: H, I, J, K, ?
- H + 1 = I
- I + 1 = J
- J + 1 = K
Following this pattern, the next letter is K + 1 = L.

Step 2: Analyze the second letter of each cluster
The second letters are: B, C, D, E, ?
- B + 1 = C
- C + 1 = D
- D + 1 = E
Following this pattern, the next letter is E + 1 = F.

Step 3: Analyze the third letter of each cluster
The third letters are: E, F, G, H, ?
- E + 1 = F
- F + 1 = G
- G + 1 = H
Following this pattern, the next letter is H + 1 = I.

Step 4: Analyze the number part of each cluster
The numbers are: 22, 29, 36, 43, ?
- 22 + 7 = 29
- 29 + 7 = 36
- 36 + 7 = 43
Following this pattern, the next number is 43 + 7 = 50.

Combining all components together gives the cluster LFI50.