What will come in the place of question (?) mark in the following number series.

?, 161, 228, 299, 372, 451

The correct option is 100.

Let's analyze the given number series to find the pattern:

?, 161, 228, 299, 372, 451

First, let's find the difference between consecutive terms in the series starting from the known values:

228 - 161 = 67

299 - 228 = 71

372 - 299 = 73

451 - 372 = 79

Observe the sequence of differences obtained: 67, 71, 73, 79.

These are consecutive prime numbers.

The prime number preceding 67 is 61.

Therefore, the difference between 161 and the unknown term (?) must be 61.

Let's calculate the missing value:

? = 161 - 61

? = 100

Thus, the number that will come in place of the question mark is 100.