Select the most appropriate option to substitute the underlined segment in the given sentence.

Dr. Aris, a renowned surgeon who has performed hundreds of delicate heart operations, will be open the new pediatric wing next week in Boston.

The correct option to substitute the underlined segment is will open.

Explanation:
1. Tense Identification: The sentence describes an event scheduled for "next week", which indicates a future action. Therefore, the main verb phrase must be in the simple future tense.
2. Grammatical Structure: In active voice, the simple future tense is formed using the modal verb will followed by the base form of the main verb (will + base verb). Here, the base form of the verb is open, making the correct structure will open.
3. Analysis of Incorrect Options:
- will opening: Incorrect. Modal verbs such as "will" must be followed by the base form of the verb, not a present participle (-ing form).
- in opening: Incorrect. This creates a prepositional phrase rather than a valid finite verb phrase needed for the sentence structure.
- is open: Incorrect. This uses the present tense and fails to properly express the future active action directed at the object ("the new pediatric wing").

Corrected Sentence:
"Dr. Aris, a renowned surgeon who has performed hundreds of delicate heart operations, will open the new pediatric wing next week in Boston."