Given below are two statements :
Statement I : Aspirin and Paracetamol belong to the class of narcotic analgesics.
Statement II : Morphine and Heroin are non-narcotic analgesics.
In the light of the above statements, choose the correct answer from the options given below.
Correct Answer :
Both Statement I and Statement II are false.
Solution :
**Step 1: Understand the classification of analgesics.**
Analgesics are drugs that relieve pain. They are broadly divided into two categories:
1. **Narcotic (opioid) analgesics** – act on opioid receptors in the brain and spinal cord. Examples include morphine, heroin, codeine, and fentanyl.
2. **Non‑narcotic (non‑opioid) analgesics** – relieve pain by other mechanisms, such as inhibition of cyclo‑oxygenase enzymes. Common examples are aspirin and paracetamol (acetaminophen).
**Step 2: Evaluate Statement I.**
Statement I claims: “Aspirin and Paracetamol belong to the class of narcotic analgesics.”
- Aspirin is a salicylate that inhibits COX‑1 and COX‑2 enzymes.
- Paracetamol (acetaminophen) is also a COX inhibitor, though its exact mechanism differs from typical NSAIDs.
Both drugs **do not act on opioid receptors** and therefore are **non‑narcotic analgesics**. Consequently, Statement I is **false**.
**Step 3: Evaluate Statement II.**
Statement II claims: “Morphine and Heroin are non‑narcotic analgesics.”
- Morphine is the prototypical opioid analgesic; it binds strongly to μ‑opioid receptors to produce potent pain relief.
- Heroin (diacetylmorphine) is a derivative of morphine and is also an opioid; it is even more lipophilic, leading to rapid brain penetration.
Both substances **are classic narcotic (opioid) analgesics**. Therefore, Statement II is **false**.
**Step 4: Combine the conclusions.**
Since Statement I is false and Statement II is also false, the correct combined assessment is:
Both Statement I and Statement II are false.
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