Rearrange the following sentences in the proper sequence to form a meaningful paragraph; then answer the questions given below them.

(A) He discovered many patients were diagnosed before turning 65.
(B) Recently, scientists found a genetic marker tied to early-onset Alzheimer’s.
(C) Alzheimer’s is a brain disorder that damages memory and thinking over time.
(D) Using this lead, Rohan studied data from 48 states in the USA.
(E) This result points to the need for early detection and preventive therapy.
(F) This gradual decline is made worse because most treatments only manage symptoms.

Which of the following should be the SECOND sentence after rearrangement?

To determine the correct sequence, we can analyze the logical links between the sentences:

1. Sentence (C) serves as the introductory sentence because it defines the core subject: "Alzheimer’s is a brain disorder that damages memory and thinking over time."

2. Sentence (F) refers back to the description in (C). The phrase "This gradual decline" in (F) directly connects to the description of the disorder that "damages memory and thinking over time" in (C). Thus, (F) logically follows (C): "This gradual decline is made worse because most treatments only manage symptoms."

3. Sentence (B) introduces a scientific development: "Recently, scientists found a genetic marker tied to early-onset Alzheimer’s."

4. Sentence (D) connects to (B) through the phrase "Using this lead" (referring to the genetic marker) and introduces Rohan: "Using this lead, Rohan studied data from 48 states in the USA."

5. Sentence (A) details the findings of Rohan's study: "He discovered many patients were diagnosed before turning 65." (Here, "He" refers to Rohan, and "before turning 65" defines "early-onset").

6. Sentence (E) concludes the paragraph by addressing the implications of the findings in (A): "This result points to the need for early detection and preventive therapy."

By arranging the sentences, we get the coherent sequence: C - F - B - D - A - E.
Therefore, the second sentence in the rearranged paragraph is F.