Directions: Rearrange the given sentences in a logical sequence to form a coherent paragraph, then answer the question below.

(A) He found that a high percentage of patients experienced functional loss before age 50.
(B) Recently, medical researchers identified a cellular protein linked to aggressive forms of Parkinson's.
(C) Parkinson’s is a progressive neurological disorder that gradually disrupts movement and motor control.
(D) Prompted by this discovery, Dr. Vance analyzed patient records from 40 major hospitals.
(E) These findings underscore the critical need for early diagnostic tools and targeted interventions.
(F) This ongoing physical decline is compounded by the reality that current medications merely address symptoms.

Which of the following sentences should be positioned LAST in the sequence after proper rearrangement?

The correct option is E.

To determine which sentence should be positioned last, let us analyze the logical flow and connections between the given sentences to construct a coherent paragraph:

1. Sentence (C) - Introductory Sentence: "Parkinson’s is a progressive neurological disorder that gradually disrupts movement and motor control."
This sentence introduces the central topic of the paragraph (Parkinson's disease) and serves as an ideal starting point.

2. Sentence (F) - Continuation: "This ongoing physical decline is compounded by the reality that current medications merely address symptoms."
The phrase "This ongoing physical decline" connects directly to the progressive disruption of movement and motor control described in sentence C.

3. Sentence (B) - New Information/Discovery: "Recently, medical researchers identified a cellular protein linked to aggressive forms of Parkinson's."
This introduces a recent research breakthrough concerning the disease.

4. Sentence (D) - Action Taken: "Prompted by this discovery, Dr. Vance analyzed patient records from 40 major hospitals."
The phrase "this discovery" directly links back to the cellular protein identification mentioned in sentence B.

5. Sentence (A) - Research Findings: "He found that a high percentage of patients experienced functional loss before age 50."
The pronoun "He" refers to Dr. Vance from sentence D, presenting the outcome of his analysis.

6. Sentence (E) - Conclusion (Last Sentence): "These findings underscore the critical need for early diagnostic tools and targeted interventions."
The phrase "These findings" summarizes the results detailed in sentence A and offers a broad concluding thought/takeaway for the paragraph.

Therefore, the complete logical order of the paragraph is C – F – B – D – A – E.
The sentence positioned LAST in the sequence is sentence E.