An old man lived in the village. He was one of the (1) ______ unfortunate people in the world. The whole village was tired (2) ______ him; he was always gloomy, he (3) ______ complained and was always in a bad mood. The (4) ______ he lived, the more vile he was becoming and the more (5) ______ were his words.

Select the most appropriate option to fill in blank number 2.

The correct answer is of.

Let us analyze the sentence structure and the usage of prepositions with the adjective "tired".
The sentence in the passage is: "The whole village was tired (2) ______ him..."

In English grammar, the adjective "tired" is followed by specific prepositions depending on the context:
1. Tired of: This is a standard phrasal adjective/prepositional collocation meaning to be weary, bored, or impatient with someone or something (e.g., "tired of his complaints").
2. Tired from: This is used when referring to physical fatigue caused by an activity (e.g., "tired from running").

Since the context of the story describes the villagers being fed up or weary of the old man's constant gloominess and complaints, the correct preposition to express this feeling of annoyance or boredom is "of". Therefore, "tired of him" is the grammatically correct and contextually appropriate choice.