Choose the word that is most nearly similar in meaning to the highlighted word: DETRIMENTAL

The correct option is Harmful.

Explanation:

The word DETRIMENTAL means causing harm, damage, or detriment (i.e., tending to cause harm).

Let's analyze the meanings of the given options:

1. Harmful: Causing or likely to cause harm, injury, or damage. This is direct and most nearly similar in meaning to "detrimental".
2. Encouraging: Giving someone support or confidence; foster or promote.
3. Advantageous: Involving or creating favorable circumstances that increase the chances of success or effectiveness.
4. Calming: Having the effect of making someone or something tranquil and quiet.

Since "Harmful" shares the exact same meaning as "Detrimental", it is the correct synonym.