The first folio of Shakespeare’s plays appeared in:

The correct option is 1623.

Explanation:
The First Folio, officially titled Mr. William Shakespeares Comedies, Histories, & Tragedies, is the first collected edition of William Shakespeare's plays. It was published in 1623, approximately seven years after his death in 1616.
This monumental volume was compiled and edited by Shakespeare's close friends and fellow actors, John Heminge and Henry Condell. The First Folio is of immense historical and literary significance because it contains 36 of Shakespeare's plays, including 18 that had never been published before (such as Macbeth, The Tempest, Twelfth Night, and Julius Caesar). Without this publication, these 18 plays might have been lost to history.